Product Overview: Citrus Bioflavonoids Hesperidin

Citrus Bioflavonoids Hesperidin is a naturally occurring flavonoid glycoside predominantly extracted from the peels of citrus fruits, including oranges, lemons, grapefruits, and tangerines. As a key member of the bioflavonoid family, hesperidin works synergistically with vitamin C to enhance its absorption, support collagen synthesis, and strengthen capillary integrity.

This high-purity hesperidin extract is widely recognized in the nutraceutical, pharmaceutical, and cosmetic industries for its antioxidant, anti-inflammatory, and vascular-protective properties. Available in powder or crystalline form, it is a versatile ingredient for dietary supplements, functional foods, skincare formulations, and pharmaceutical applications.


Scientific & Botanical Background

Source & Extraction

  • Botanical Origin: Citrus aurantium (Bitter Orange), Citrus sinensis (Sweet Orange), and other Citrus species.
  • Plant Part Used: Dried citrus peels (flavedo and albedo layers).
  • Extraction Method: Solvent extraction (water & ethanol) followed by purification and crystallization to ensure high bioactivity and stability.
  • Active Compound: Hesperidin (C₂₈H₃₄O₁₅), a flavanone glycoside with potent free radical scavenging and vascular-supporting properties.

Chemical & Physical Properties

ParameterSpecification
AppearanceOrange-yellow to yellow fine powder
Assay (Dry Basis)98.0% – 102.0% (UV)
SolubilityFreely soluble in water (enhanced bioavailability)
pH Value4.5 – 6.5
Loss on Drying≤ 5% (GB 5009.3)
Sulphated Ash≤ 0.5% (GB 5009.4)
Heavy MetalsAs ≤ 1.0 ppm, Pb ≤ 2.0 ppm, Hg ≤ 1.0 ppm
MicrobiologicalTotal Plate Count ≤ 10,000 cfu/g, Yeast & Mold ≤ 100 cfu/g, E. coli & Staphylococcus Negative

Key Benefits & Applications of Citrus Bioflavonoids Hesperidin

1. Nutraceutical & Dietary Supplement Applications

Hesperidin is a bioactive compound with multiple health benefits, making it a high-demand ingredient for:

  • Cardiovascular Support: Enhances blood circulation, reduces capillary fragility, and supports venous health.
  • Antioxidant & Anti-Inflammatory Effects: Neutralizes free radicals, reducing oxidative stress and inflammation.
  • Immune Modulation: Works synergistically with vitamin C to boost immune function and collagen production.
  • Metabolic Health: May aid in glucose metabolism and lipid regulation, supporting metabolic wellness.
  • Joint & Connective Tissue Health: Promotes collagen integrity, benefiting joint mobility and skin elasticity.

Common Dosage Forms:

  • Capsules & Tablets (500 mg – 1,000 mg per serving)
  • Powder Blends (for functional beverages & nutritional powders)
  • Softgels & Chewables (for enhanced bioavailability)

2. Cosmetic & Skincare Applications

Hesperidin’s dermatological benefits make it a valuable active ingredient in:

  • Anti-Aging Formulations: Reduces oxidative damage, improving skin firmness and radiance.
  • Brightening & Even-Tone Products: Inhibits melanin production, helping to fade dark spots and hyperpigmentation.
  • Soothing & Barrier-Repair Creams: Strengthens the skin moisture barrier, reducing dryness and irritation.
  • Sun Protection Enhancers: Works alongside SPF ingredients to neutralize UV-induced free radicals.

Formulation Compatibility:

  • Water-based serums & lotions
  • Emulsions & creams
  • Masks & leave-on treatments

3. Pharmaceutical & Functional Food Applications

  • Vascular Health Supplements: Used in venotonic formulations to support circulatory function.
  • Functional Beverages: Added to juices, teas, and energy drinks for antioxidant enrichment.
  • Sports Nutrition: Included in recovery supplements for anti-inflammatory support.

Why Choose Botanical Essence’s Citrus Bioflavonoids Hesperidin?

1. Superior Quality & Purity

  • High-Purity Extraction: Minimum 98% hesperidin content (UV-tested).
  • Strict Quality Control: Compliant with GB, USP, and EP standards.
  • Heavy Metal & Microbial Testing: Ensures safety and regulatory compliance for global markets.

2. Sustainable & Traceable Sourcing

  • Ethically Sourced Citrus Peels: From GMP-certified suppliers with non-GMO, pesticide-free raw materials.
  • Eco-Friendly Extraction: Uses food-grade solvents (water & ethanol) with low environmental impact.

3. Customizable & Scalable Supply

  • Flexible Packaging: Available in 1 kg, 5 kg, 10 kg, and 25 kg sealed drums or bags.
  • Private Label & Bulk Options: Tailored solutions for manufacturers, contract formulators, and private-label brands.
  • Stable Shelf Life: 24 months when stored in a cool, dry place (below 25°C, away from direct sunlight).

4. Regulatory & Certification Support

  • ISO 9001 & HACCP Certified manufacturing.
  • Halal & Kosher compliant (available upon request).
  • Third-Party Testing: COA (Certificate of Analysis) provided for every batch.

Technical & Formulation Considerations

Solubility & Stability

  • Water-Soluble: Easily dispersible in aqueous solutions, making it ideal for beverages, syrups, and liquid supplements.
  • pH Stability: Remains stable in pH 4.5–6.5, compatible with most nutraceutical and cosmetic formulations.
  • Heat & Light Sensitivity: Store in airtight, opaque containers to prevent degradation.

Synergistic Ingredients

Hesperidin works well with:

  • Vitamin C (enhances absorption & antioxidant effects)
  • Quercetin & Rutin (boosts vascular & immune support)
  • Collagen Peptides (supports skin & joint health)
  • Hyaluronic Acid (enhances moisture retention in skincare)

Recommended Usage Levels

ApplicationTypical Dosage
Dietary Supplements500 mg – 1,000 mg/day
Functional Foods100 mg – 500 mg/serving
Skincare Formulations0.5% – 2% (in creams/serums)

Where to Buy Premium Citrus Bioflavonoids Hesperidin?

Botanical Essence is a leading supplier of high-quality hesperidin extract, specializing in plant-based ingredients for the nutraceutical, cosmetic, and pharmaceutical industries.

Why Partner With Us?

✅ GMP-Standard Manufacturing – Strict quality control from raw material to final product.
✅ Competitive Pricing – Bulk discounts for wholesale, OEM, and private-label clients.
✅ Fast & Reliable Shipping – Global logistics with DHL, FedEx, and sea freight options.
✅ Technical & Formulation Support – Expert guidance for product development and regulatory compliance.
✅ Free Samples Available – Request a sample for testing before bulk orders.

Contact Us for Quotations & Bulk Inquiries:
📧 Email: [email protected]
🌍 Global Supply Chain: Serving North America, Europe, Asia, and beyond


Frequently Asked Questions (FAQs)

Q: Is Citrus Bioflavonoids Hesperidin safe for long-term use?

A: Yes, hesperidin is generally recognized as safe (GRAS) when consumed within recommended dosages. It has been extensively studied for safety and efficacy in human nutrition.

Q: Can hesperidin be used in vegan or vegetarian products?

A: Absolutely. Our hesperidin extract is 100% plant-derived, making it suitable for vegan, vegetarian, and halal/kosher formulations.

Q: What is the difference between hesperidin and hesperidin methyl chalcone?

A: Hesperidin methyl chalcone (HMC) is a modified, more bioavailable form of hesperidin, offering enhanced absorption in supplements. Our standard hesperidin extract is the natural glycoside form, ideal for general applications.

Q: Do you provide third-party testing certificates?

A: Yes, every batch comes with a detailed COA, including HPLC/UV testing, heavy metal analysis, and microbial reports.

Q: What is the minimum order quantity (MOQ)?

A: Our MOQ starts at 1 kg, with flexible bulk pricing for larger orders. Contact us for custom packaging and private-label options.


Botanical Essence – Your Trusted Partner for Premium Plant Extracts & Nutraceutical Ingredients.

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