Product Overview
Dihydromyricetin (DHM) Bulk is a highly bioavailable flavanonol compound naturally derived from botanical sources such as Ampelopsis grossedentata (also known as Vitis amurensis) and Hovenia dulcis. As a potent flavonoid, dihydromyricetin bulk exhibits remarkable antioxidant, anti-inflammatory, neuroprotective, and hepatoprotective properties, making it a sought-after ingredient in nutraceuticals, functional foods, dietary supplements, and pharmaceutical formulations.
Scientific studies highlight its ability to scavenge free radicals (DPPH, IC₅₀ = 4.36 µM), modulate GABAₐ receptors, and mitigate ethanol-induced neurotoxicity by reducing loss of righting reflex (LORR) in animal models. Additionally, long-term administration (2 mg/kg for three months) has demonstrated cognitive-enhancing effects in Alzheimer’s disease mouse models, reinforcing its potential in brain health and longevity applications.
At Botanical Essence, we provide high-purity dihydromyricetin bulk powder with ≥98% active content, ensuring consistent potency, superior solubility, and exceptional stability for industrial and commercial use.
Scientific & Functional Benefits of Dihydromyricetin Bulk
1. Powerful Antioxidant & Cellular Protection
As a flavonoid antioxidant, dihydromyricetin bulk neutralizes reactive oxygen species (ROS) and oxidative stress, protecting cells from DNA damage, lipid peroxidation, and premature aging. Its free radical-scavenging capacity supports cardiovascular health, skin vitality, and immune function, making it a valuable addition to anti-aging supplements and functional beverages.
2. Anti-Inflammatory & Immune Modulation
DHM demonstrates strong anti-inflammatory effects by inhibiting pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and reducing eosinophils, macrophages, lymphocytes, and neutrophils in preclinical studies. This makes bulk dihydromyricetin an ideal ingredient for joint health, respiratory support, and autoimmune-related formulations.
3. Alcohol Detoxification & Liver Support
One of the most well-documented benefits of dihydromyricetin bulk is its hangover-relief and liver-protective properties. It:
- Accelerates alcohol metabolism by enhancing ADH (alcohol dehydrogenase) and ALDH2 (aldehyde dehydrogenase) activity
- Reduces acetaldehyde toxicity, minimizing nausea, headaches, and fatigue post-alcohol consumption
- Protects liver cells from oxidative damage, supporting hepatic detoxification pathways
These properties make DHM powder a key ingredient in hangover recovery supplements, liver detox formulas, and functional alcoholic beverages.
4. Neuroprotective & Cognitive Enhancement
Dihydromyricetin bulk supports brain health through multiple mechanisms:
- Modulates GABAₐ receptors, promoting calmness and stress relief
- Reduces cortisol levels, aiding in mood stabilization and anxiety management
- Enhances synaptic plasticity, improving memory, focus, and cognitive resilience
- Protects against neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) by inhibiting amyloid-beta plaque formation
5. Athletic Performance & Mitochondrial Support
For sports nutrition and endurance athletes, bulk dihydromyricetin offers:
- Improved oxygen utilization under hypoxic (high-altitude) conditions
- Enhanced mitochondrial biogenesis in skeletal muscle cells, boosting stamina and recovery
- Reduced exercise-induced oxidative stress, supporting muscle repair and fatigue resistance
6. Metabolic & Cardiovascular Health
Emerging research suggests that dihydromyricetin bulk may:
- Regulate blood glucose levels by improving insulin sensitivity
- Support lipid metabolism, reducing LDL cholesterol and triglycerides
- Promote endothelial function, aiding in healthy blood pressure and circulation
Product Specifications & Quality Assurance
At Botanical Essence, we adhere to strict GMP, ISO, and HACCP standards to ensure pharmaceutical-grade purity, consistency, and safety in every batch of dihydromyricetin bulk powder.
Certificate of Analysis (COA) – Dihydromyricetin Bulk
| Parameter | Specification | Test Result | Method |
|---|---|---|---|
| Active Content (HPLC) | ≥98.00% | 98.07% | HPLC |
| Appearance | Fine Powder | Conforms | Visual |
| Color | Light Yellow / Off-White | Off-White | Visual |
| Odor | Characteristic | Conforms | Organoleptic |
| Taste | Characteristic | Conforms | Organoleptic |
| Loss on Drying | ≤2.0% | 1.68% | 2h at 105°C |
| Ash Content | ≤1.0% | 0.44% | 5h at 600°C |
| Heavy Metals | |||
| - Total Heavy Metals | ≤10 ppm | Conforms | ICP-MS |
| - Arsenic (As) | ≤1.0 ppm | Conforms | GB 5009.11-2014 |
| - Lead (Pb) | ≤1.0 ppm | Conforms | GB 5009.12-2017 |
| - Mercury (Hg) | ≤0.5 ppm | Conforms | GB 5009.17-2014 |
| - Cadmium (Cd) | ≤1.0 ppm | Conforms | GB 5009.15-2014 |
| Microbiological Tests | |||
| - Total Plate Count | ≤1000 cfu/g | Conforms | CP2015 |
| - Yeast & Mold | ≤100 cfu/g | Conforms | CP2015 |
| - E. coli | Negative | Conforms | CP2015 |
| - Salmonella | Negative | Conforms | CP2015 |
| - Staphylococcus | Negative | Conforms | CP2015 |
Additional Quality & Compliance Features
✅ Non-GMO, Gluten-Free, Vegan-Friendly
✅ No Artificial Additives or Preservatives
✅ Solvent-Free Extraction (Ethanol/Water-Based)
✅ Third-Party Lab Tested for Purity & Potency
✅ Complies with USP, EP, and JP Standards
✅ Kosher & Halal Certification Available Upon Request
Technical & Formulation Details
Source & Extraction Process
- Botanical Origin: Ampelopsis grossedentata (primary source)
- Extraction Method: Ethanol-water extraction followed by column chromatography purification
- Solvent Residue: <50 ppm (meets ICH guidelines)
- Particle Size: 80-120 mesh (customizable upon request)
Physical & Chemical Properties
| Property | Details |
|---|---|
| Molecular Formula | C₁₅H₁₂O₆ |
| Molecular Weight | 288.25 g/mol |
| Melting Point | 218–220°C |
| Solubility | Soluble in ethanol, DMSO, and warm water (slightly soluble in cold water) |
| Stability | Stable under normal storage conditions (protect from light & moisture) |
| pH (1% Solution) | 4.5–6.5 |
Shelf Life & Storage Recommendations
- Shelf Life: 2 years (when stored properly)
- Storage Conditions:
- Sealed in airtight containers
- Store in a cool, dry place (≤25°C)
- Avoid direct sunlight and humidity
- Packaging Options:
- 1 kg, 5 kg, 10 kg, 25 kg (aluminum foil bags or fiber drums)
- Custom packaging available for bulk orders
Industry Applications of Dihydromyricetin Bulk
1. Nutraceuticals & Dietary Supplements
- Hangover relief capsules & tablets
- Liver detox & metabolic support formulas
- Brain health & cognitive enhancement supplements
- Anti-aging & antioxidant blends
- Stress & mood support complexes
2. Functional Foods & Beverages
- Alcohol-infused beverages (hangover-free options)
- Energy drinks & sports nutrition products
- Functional teas & herbal infusions
- Fortified health bars & snacks
3. Pharmaceutical & Cosmeceutical Applications
- Hepatoprotective drug formulations
- Topical antioxidant serums & creams
- Neuroprotective nutraceuticals
4. Animal Nutrition & Feed Additives
- Livestock liver support supplements
- Pet health & detox formulations
Why Choose Botanical Essence for Dihydromyricetin Bulk?
✔ Premium Quality & Consistency – ≥98% purity with batch-to-batch uniformity
✔ Ethical & Sustainable Sourcing – Wild-harvested or organically cultivated raw materials
✔ Advanced Extraction Technology – Solvent-free, high-efficiency purification
✔ Full Traceability & Transparency – COA, MSDS, and third-party testing reports available
✔ Competitive Pricing & Bulk Discounts – Cost-effective solutions for large-scale production
✔ Global Shipping & Logistics Support – Fast, reliable delivery with proper documentation
✔ Dedicated Technical & Regulatory Assistance – Expert guidance on formulation, compliance, and market trends
How to Purchase Dihydromyricetin Bulk
Botanical Essence is a trusted supplier of high-purity dihydromyricetin bulk powder for manufacturers, formulators, and distributors worldwide.
📧 Contact us today for:
✅ Bulk pricing & wholesale inquiries
✅ Custom formulations & private labeling
✅ Sample requests & technical data sheets
✅ Regulatory compliance support (FDA, EU, etc.)
Email: [email protected]
Your trusted partner in premium botanical extracts.
