Introduction to Dihydromyricetin (DHM) Powder
Dihydromyricetin powder (also known as DMY, DHM, or 3,5,7,3',4',5'-hexahydroxy-2,3-dihydroflavonol) is a highly bioavailable flavonoid compound derived from natural plant sources, primarily vine tea (Ampelopsis grossedentata) and grapevine (Vitis vinifera). First isolated in 1960 from Ampelopsis meliaefolia and later identified in vine tea in 1996, this potent polyphenol has gained significant attention in nutraceuticals, functional foods, and pharmaceutical research due to its antioxidant, hepatoprotective, hypoglycemic, and lipid-regulating properties.
As a leading botanical extract supplier, Botanical Essence provides high-purity dihydromyricetin powder (≥98% by HPLC) with strict quality control, traceable sourcing, and compliance with international safety standards. Our DHM powder is ideal for dietary supplement manufacturers, functional food producers, and pharmaceutical developers seeking a natural, science-backed ingredient with broad-spectrum health benefits.
Scientific Background & Active Mechanisms
Dihydromyricetin is a flavonol glycoside with a unique molecular structure that contributes to its strong antioxidant and free-radical scavenging abilities. The phenolic hydroxyl groups (3’, 4’, 5’ positions on the B-ring) play a key role in its cellular protective effects, including:
- Enhancing mitochondrial function by reducing oxidative stress
- Modulating glucose and lipid metabolism via AMPK and PPAR pathways
- Accelerating acetaldehyde breakdown to mitigate alcohol-induced liver damage
- Supporting detoxification by promoting glutathione (GSH) synthesis
Extensive preclinical and clinical studies have demonstrated its potential in liver protection, metabolic regulation, and neuroprotective applications, making it a high-demand ingredient in hangover relief supplements, liver support formulas, and metabolic health products.
Key Benefits & Applications of Dihydromyricetin Powder
1. Powerful Antioxidant & Cellular Protection
- Neutralizes free radicals (ROS, superoxide anions) more effectively than vitamin C and E in some models
- Protects against oxidative DNA damage and lipid peroxidation
- Supports longevity and anti-aging by reducing cellular senescence
2. Liver Protection & Alcohol Detoxification
- Accelerates acetaldehyde metabolism, reducing alcohol toxicity
- Prevents glutathione depletion and lowers malondialdehyde (MDA) levels in liver cells
- Reduces hepatic steatosis (fatty liver) by regulating lipid synthesis
- Clinical studies suggest DHM may alleviate hangover symptoms and protect against alcohol-induced liver injury
3. Blood Sugar & Lipid Regulation
- Inhibits α-glucosidase and α-amylase, slowing carbohydrate absorption
- Improves insulin sensitivity and reduces fasting blood glucose
- Lowers triglycerides and LDL cholesterol while increasing HDL
- Supports metabolic syndrome management by modulating adipogenesis
4. Anti-Inflammatory & Immune Support
- Inhibits NF-κB and COX-2 pathways, reducing chronic inflammation
- Enhances immune response by modulating cytokine production
- Potential antibacterial and antiviral effects (studies ongoing)
5. Neuroprotective & Cognitive Benefits
- Protects against neurodegenerative diseases (Alzheimer’s, Parkinson’s) by reducing amyloid-beta plaque formation
- Enhances GABAergic activity, promoting relaxation and stress relief
- May support cognitive function by improving blood flow to the brain
6. Additional Health Benefits
- Expectorant & cough relief (traditional use in Chinese medicine)
- Kidney stone prevention by reducing calcium oxalate crystallization
- Anti-fatigue & endurance enhancement (studies in athletic performance)
Product Specifications & Quality Standards
At Botanical Essence, we ensure pharmaceutical-grade dihydromyricetin powder with consistent purity, safety, and efficacy. Below are the detailed specifications of our 98% DHM powder:
Chemical & Physical Properties
| Parameter | Specification | Test Result | Method |
|---|---|---|---|
| Dihydromyricetin (HPLC) | ≥98.00% | 98.07% | HPLC |
| Appearance | Fine powder | Conforms | Visual |
| Color | Light yellow to off-white | Off-white | Visual |
| Odor | Characteristic | Conforms | Organoleptic |
| Taste | Characteristic (slightly bitter) | Conforms | Organoleptic |
Purity & Contaminant Testing
| Parameter | Specification | Test Result | Method |
|---|---|---|---|
| Loss on Drying | ≤2.0% | 1.68% | 2h at 105°C |
| Ash Content | ≤1.0% | 0.44% | 5h at 600°C |
| Total Heavy Metals | ≤10 ppm | Conforms | ICP-MS |
| Arsenic (As) | ≤1.0 ppm | Conforms | GB 5009.11-2014 |
| Lead (Pb) | ≤1.0 ppm | Conforms | GB 5009.12-2017 |
| Mercury (Hg) | ≤0.5 ppm | Conforms | GB 5009.17-2014 |
| Cadmium (Cd) | ≤1.0 ppm | Conforms | GB 5009.15-2014 |
Microbiological Safety
| Parameter | Specification | Test Result | Method |
|---|---|---|---|
| Total Plate Count | ≤1,000 cfu/g | Conforms | CP2015 |
| Yeast & Mold | ≤100 cfu/g | Conforms | CP2015 |
| E. coli | Negative | Conforms | CP2015 |
| Salmonella | Negative | Conforms | CP2015 |
| Staphylococcus | Negative | Conforms | CP2015 |
Compliance Certifications:
✔ ISO 22000 (Food Safety Management)
✔ HACCP Certified
✔ GMP (Good Manufacturing Practice)
✔ Halal & Kosher Available (Upon Request)
Manufacturing Process & Sourcing
Raw Material Origin
- Primary Source: Ampelopsis grossedentata (Vine Tea) – Organically cultivated in China’s Hunan and Jiangxi provinces
- Secondary Source: Vitis vinifera (Grapevine leaves) – Sustainably harvested from certified farms
- Non-GMO, Pesticide-Free, No Artificial Additives
Extraction & Purification
- Solvent-Free Extraction: Uses water or ethanol-based methods to preserve bioactive compounds
- Column Chromatography: Ensures high-purity DHM isolation (98%+)
- Spray Drying: Produces fine, free-flowing powder with excellent solubility
- Third-Party Testing: Every batch undergoes HPLC, heavy metal, and microbial analysis
Solubility & Stability
- Soluble in: Water (moderate), ethanol, propylene glycol
- Stable under: Normal storage conditions (cool, dry, away from light)
- Shelf Life: 2 years (when stored properly in sealed packaging)
Industry Applications & Formulation Guidance
1. Dietary Supplements & Nutraceuticals
- Hangover relief capsules/tablets (50-500 mg per serving)
- Liver detox & metabolic support blends
- Antioxidant & anti-aging formulations
- Sports nutrition (recovery & endurance)
2. Functional Foods & Beverages
- Energy drinks & recovery shots (0.1-0.5% DHM)
- Herbal teas & health tonics
- Fortified snacks & protein bars
- Alcohol-free "sober-up" beverages
3. Pharmaceutical & Cosmeceutical Uses
- Hepatoprotective drug development
- Topical antioxidants in skincare (anti-aging serums)
- Neuroprotective supplements
4. Animal Nutrition & Feed Additives
- Livestock liver health support
- Poultry & aquaculture feed enhancers
Recommended Dosage (For Human Consumption)
| Application | Typical Dosage | Form |
|---|---|---|
| Dietary Supplements | 50-500 mg/day | Capsules, tablets, powder |
| Functional Beverages | 10-100 mg/serving | Liquid extracts, teas |
| Topical Use | 0.5-2% in formulations | Serums, creams |
Note: Always consult a healthcare professional or regulatory expert for dosage compliance in your target market.
Packaging, Storage & Shipping
Packaging Options
- Small Orders: 1 kg, 5 kg aluminum foil bags (with nitrogen flush)
- Bulk Orders: 10 kg, 20 kg, 25 kg fiber drums (double-lined with PE bags)
- Custom Packaging: Available upon request (private labeling, bulk containers)
Storage Recommendations
- Temperature: Store in a cool, dry place (15-25°C)
- Humidity: Keep relative humidity below 60%
- Light Exposure: Avoid direct sunlight (use opaque or amber containers)
- Shelf Life: 24 months from production date (if stored properly)
Global Shipping & Logistics
- Fast Delivery: DHL, FedEx, UPS, or sea freight (depending on order size)
- Documentation: COA, MSDS, Phytosanitary Certificate, Customs Declaration
- Lead Time: 3-7 days for stock items, 15-20 days for bulk orders
Why Choose Botanical Essence as Your Dihydromyricetin Supplier?
✅ Premium Quality: ≥98% purity DHM powder with third-party lab verification
✅ Sustainable Sourcing: Organic, non-GMO, ethically harvested raw materials
✅ Regulatory Compliance: Meets USP, EP, and FDA food-grade standards
✅ Custom Solutions: Private labeling, bulk discounts, and OEM formulations available
✅ Reliable Supply Chain: Stable inventory, fast shipping, and competitive pricing
✅ Technical Support: Dedicated R&D team for formulation guidance
How to Order Dihydromyricetin Powder
Botanical Essence is your trusted partner for high-quality dihydromyricetin powder at competitive wholesale prices. Whether you need small samples for R&D or bulk orders for commercial production, we provide flexible solutions tailored to your needs.
📧 Contact Us Today:
Email: [email protected]
Subject: Inquiry for Dihydromyricetin Powder (Specify Quantity & Requirements)
We offer:
✔ Free samples (for qualified buyers)
✔ Bulk pricing discounts
✔ Fast lead times & secure logistics
✔ Technical data sheets & formulation support
Start your order now and experience the Botanical Essence difference!
