INTRODUCTION TO APIGENIN BULK POWDER
Apigenin Bulk Powder, also known as apigenin, chemically identified as 4,5,7-trihydroxyflavone, is a flavonoid notable for its diverse biological activities. Commonly found in plants like parsley, celery, chamomile, orange, thyme, and botanical beverages, apigenin is particularly abundant in celery leaves. Biztanleria Botanic as a special natural compound, apigenin poses low toxicity and exhibits potential antioxidant, anti-inflammatory, antiviral, liver-protective, and anticancer properties.
CERTIFICATE OF ANALYSIS (COA) FOR APIGENIN BULK POWDER
| Item | Specification | Assay (Apigenin) |
|---|---|---|
| Chemical & Physical Control | ||
| Appearance | Fine Powder | 98.00% |
| Color | Light-yellow | |
| Odor | Typical | |
| Taste | Typical | |
| Particle size | NLT 100% Through 80 mesh | |
| Loss on drying | ≤2.0% | |
| Residue on ignition | ≤2.0% | |
| Heavy Metals | ≤10 ppm | |
| Arsenic (As) | ≤1 ppm | |
| Lead (Pb) | ≤1 ppm | |
| Mercury (Hg) | ≤0.1 ppm | |
| Cadmium (Cd) | ≤1 ppm | |
| Microbiological Control | ||
| Total Plate Count | ≤10,000 cfu/g | |
| Total Yeast & Mold | ≤1000 cfu/g | |
| E. coli | Negative |
APIGENIN BULK POWDER IN HEPATOCELLULAR CARCINOMA (HCC) TREATMENT
HCC is the primary type of liver cancer, ranking fifth among global cancers and second in cancer-related deaths. With low cure and survival rates, postoperative recurrence, metastasis, and mortality are extremely high. As a natural flavonoid, apigenin demonstrates functions that inhibit cell proliferation, induce cell apoptosis and differentiation, enhance chemotherapeutic drug toxicity, and reduce drug resistance in HCC treatment.
- Inhibition of cell proliferation in HCC: Apigenin's inhibitory effect on human hepatoma cell lines is concentration- and time-dependent, potentially regulating cell cycle and oncogenes.
- Induction of apoptosis and autophagy in HCC: Apigenin bulk powder induces liver cancer cell apoptosis and inhibits tumor growth by directly acting on mitochondria and through multiple cell signaling pathways, including PI3K/Akt/mTOR.
- Promoting cell differentiation of HCC: Apigenin shows potential in inducing liver cancer cell differentiation for HCC treatment.
- Inhibition of HCC invasion and metastasis: Apigenin regulates Epithelial-Mesenchymal Transition (EMT) markers and inhibits human hepatoma cell Bel-7402 invasion and migration.
- Inhibition of angiogenesis in HCC: Apigenin bulk powder inhibits tumor blood vessel growth to treat HCC.
- Suppression of HCC by immunomodulation: Apigenin increases TNF-α, IFN-1, and caspase activities, inducing HepG2 cell apoptosis.
- Synergism, sensitization, and detoxification: Apigenin improves chemotherapy drug sensitivity and reduces drug resistance in liver cancer cells.
APIGENIN BULK POWDER EXTRACTION
Apigenin has been primarily extracted from celery, Haizhou Xiangju, Compositae, and legumes, with celery leaves having the highest content (20 mg/g~30 mg/g). Extraction methods include organic solvent extraction, ultrasonic microwave-assisted extraction, enzyme extraction, acid extraction, and subcritical water extraction, with organic solvent extraction being the most commonly used.
Apigenin's low toxicity and anticancer properties have drawn attention, with numerous studies confirming its anti-HCC effects and synergistic potential with chemotherapeutic drugs. To explore apigenin further, please contact us through our website or email at [email protected].
Popular Searches: apigenin bulk powder, apigenin powder bulk, China suppliers, manufacturers, factory, wholesale, quotation, low price, in stock, buy discount, free sample, made in China, Canavalia Gladiata Extract Powder.
