What Is Caffeic Acid Powder?
Caffeic Acid Powder (CAS: 331-39-5), chemically known as 3,4-dihydroxycinnamic acid, is a naturally occurring phenolic compound found in a wide range of medicinal plants. It is prominently present in:
- Goldenrod (Solidago spp., Compositae)
- Hawthorn (Shanlihong, Rosaceae)
- Eucommia ulmoides (Du Zhong, Eucommiaceae)
- Black Cohosh (Cimicifuga racemosa, Ranunculaceae)
- Artichoke (Cynara scolymus, Asteraceae)
- Thyme (Thymus vulgaris, Lamiaceae)
- Valerian (Valeriana officinalis, Caprifoliaceae)
- Citrus fruits (Rutaceae)
- Eurasian water chestnut (Trapa natans, Trapaceae)
As a bioactive polyphenol, caffeic acid powder is widely recognized for its vascular-protective, antioxidant, and immune-modulating properties. It supports hemostatic function by enhancing coagulation factor activity, promoting platelet aggregation, and stimulating leukocyte production, making it a valuable ingredient in nutraceuticals, pharmaceuticals, and functional foods.
Key Specifications of Caffeic Acid Powder
| Parameter | Details |
|---|---|
| Product Name | Caffeic Acid Powder |
| Chemical Formula | C₉H₈O₄ |
| Molecular Weight | 180.16 g/mol |
| Purity | 99% (HPLC) |
| Appearance | Light yellow to off-white fine powder |
| Solubility | Soluble in ethanol, methanol, DMSO; slightly soluble in water |
| Melting Point | 223–225°C |
| Storage | Store in a cool, dry place; protect from light and moisture |
| Shelf Life | 2 years (under proper storage conditions) |
| Packaging | 1kg–25kg (aluminum foil bags, vacuum-sealed); bulk options: fiber drums, glass/plastic containers |
| Origin | Shaanxi, China (GMP-certified facility) |
Extraction & Manufacturing Process
At Botanical Essence, we employ advanced extraction techniques to ensure high-purity caffeic acid powder with consistent potency and bioactivity. Below are two industry-standard extraction methods used for different botanical sources:
1. Extraction from Black Cohosh (Cimicifuga spp.)
- Step 1: Rhizomes are macerated in methanol for optimal solvent penetration.
- Step 2: The extract undergoes reduced-pressure concentration to remove methanol.
- Step 3: The residue is dissolved in heated water, and hot filtration removes insoluble impurities.
- Step 4: After cooling, benzene extraction is performed, followed by washing with 1% sodium bicarbonate solution to isolate caffeic acid.
- Step 5: Acidification with dilute HCl liberates the organic acid, which is then re-extracted with benzene.
- Step 6: Final vacuum concentration removes benzene, yielding a highly enriched caffeic acid extract.
2. Extraction from Artichoke (Cirsium arvense var. integrifolium)
- Step 1: 50g of dried artichoke is decocted in 500mL water for 30 minutes, with two extraction cycles for maximum yield.
- Step 2: The filtrate is concentrated to 400mL via electric heating.
- Step 3: Ethyl acetate extraction is performed, followed by n-butanol partitioning to refine the compound.
- Step 4: 95% ethanol precipitation isolates the active fraction.
- Step 5: Lead acetate saturation and sulfuric acid deleading purify the extract.
- Step 6: pH adjustment (6.0) with potassium hydroxide and recrystallization in water yield high-purity caffeic acid crystals.
Our GMP-compliant facilities ensure batch-to-batch consistency, with HPLC and UV-Vis spectroscopy used for quality verification.
Health Benefits & Functional Applications
Caffeic acid powder is a versatile bioactive ingredient with scientifically supported benefits for human health and industrial applications:
1. Hematological & Cardiovascular Support
- Enhances platelet aggregation and white blood cell (WBC) production, aiding in thrombocytopenia and leukopenia management.
- Strengthens microvascular integrity, reducing capillary fragility.
- Promotes coagulation factor activity, supporting hemostatic function.
2. Potent Antioxidant & Free Radical Scavenger
- Inhibits lipid peroxidation more effectively than α-tocopherol (Vitamin E), BHA, BHT, and Trolox.
- Neutralizes reactive oxygen species (ROS), protecting cells from oxidative stress.
- Synergizes with other antioxidants (e.g., ferulic acid, chlorogenic acid) in anti-aging and skin-care formulations.
3. Neuroprotective & Cognitive Enhancement
- Protects against neurodegenerative diseases, including Alzheimer’s and Parkinson’s, by reducing neuroinflammation.
- Supports synaptic function and enhances memory retention.
- May help in managing senile dementia through amyloid-beta plaque inhibition.
4. Anti-Inflammatory & Immunomodulatory Effects
- Modulates cytokine production, reducing chronic inflammation.
- Supports immune response by enhancing macrophage and lymphocyte activity.
5. Antimicrobial & Antiviral Properties
- Exhibits antibacterial activity against Gram-positive and Gram-negative bacteria.
- Potential antiviral effects against herpes simplex virus (HSV) and influenza.
6. Skin & Cosmetic Applications
- Inhibits tyrosinase activity, reducing melanin production for skin brightening.
- Promotes collagen synthesis, improving skin elasticity and anti-aging effects.
- Used in topical formulations for acne treatment and wound healing.
Challenges & Solutions in Caffeic Acid Utilization
Despite its broad therapeutic potential, caffeic acid faces bioavailability and stability limitations:
Key Challenges
✅ Poor Oral Absorption – Low gastrointestinal permeability limits systemic availability.
✅ Rapid Metabolism & Degradation – First-pass metabolism and enzymatic breakdown reduce efficacy.
✅ Chemical Instability – Oxidation and isomerization in solution affect shelf life.
Industry-Proven Solutions
- Nanotechnology & Liposomal Encapsulation
- Improves solubility and bioavailability via nanoparticle delivery systems.
- Enhances cellular uptake for better therapeutic outcomes.
- Prodrug Formulation
- Esterification or conjugation with carriers (e.g., choline, phospholipids) for controlled release.
- Protects against premature degradation in the digestive tract.
- Microencapsulation
- Shields caffeic acid from light, heat, and moisture using cyclodextrins or polymeric coatings.
- Extends shelf life in functional foods and beverages.
- Synergistic Blending
- Combining with piperine (black pepper extract) enhances absorption by 2000% via P-glycoprotein inhibition.
Industrial Applications of Caffeic Acid Powder
| Industry | Applications |
|---|---|
| Nutraceuticals | Immune-boosting supplements, antioxidant capsules, cardiovascular health formulas |
| Pharmaceuticals | Hemostatic agents, anti-inflammatory drugs, neuroprotective medications |
| Cosmetics | Anti-aging serums, skin-brightening creams, acne treatments |
| Food & Beverages | Natural preservative, functional ingredient in energy drinks, antioxidant-enriched foods |
| Agriculture | Plant growth regulator, natural pesticide |
| Research & Development | Reference standard for HPLC, biochemical studies, drug formulation |
Quality Assurance & Certifications
At Botanical Essence, we prioritize product purity, safety, and traceability:
✔ HPLC & UV-Vis Testing – ≥99% purity verified in every batch.
✔ Heavy Metal & Microbial Analysis – Complies with USP, EP, and FDA standards.
✔ Non-GMO & Allergen-Free – No pesticides, solvents, or artificial additives.
✔ ISO 9001 & HACCP Certified – Stringent quality control from raw material to final product.
✔ Kosher & Halal Certified – Suitable for global dietary requirements.
✔ REACH & FDA DMF Listed – Regulatory compliance for international markets.
Why Choose Botanical Essence for Caffeic Acid Powder?
✅ Premium Botanical Sourcing – Wildcrafted and organically cultivated raw materials from Shaanxi’s pristine regions.
✅ State-of-the-Art Extraction – Supercritical CO₂ and solvent-free methods for maximum potency.
✅ Customizable Specifications – Tailored particle size, purity levels, and packaging for B2B clients.
✅ Competitive Pricing – Bulk discounts for wholesale, OEM, and private-label orders.
✅ Reliable Supply Chain – Stable inventory with fast global shipping (DHL, FedEx, sea freight).
✅ Technical & Regulatory Support – Full documentation (COA, MSDS, TDS) for smooth import/export compliance.
Packaging & Storage Guidelines
| Packaging Option | Suitable For | Shelf Life |
|---|---|---|
| 1kg–5kg (Aluminum Foil Bag, Vacuum-Sealed) | Small-scale R&D, lab use | 2 years |
| 10kg–25kg (Fiber Drum with Inner Liner) | Bulk industrial use | 2 years |
| Custom Packaging (Glass/Plastic Containers) | Pharmaceutical-grade applications | 2 years |
Storage Recommendations:
- Keep in a cool, dry place (≤25°C).
- Avoid direct sunlight and moisture.
- Seal tightly after opening to prevent oxidation.
How to Order Caffeic Acid Powder
Botanical Essence is a trusted global supplier of high-purity caffeic acid powder for nutraceutical, pharmaceutical, and cosmetic industries.
📧 Contact Us Today:
Email: [email protected]
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