What Is Celery Root Extract?

Celery Root Extract is a highly concentrated botanical derivative obtained from the roots of Apium graveolens (celery), renowned for its rich content of apigenin—a bioflavonoid with exceptional pharmacological and nutritional benefits. Chemically known as 4',5,7-trihydroxyflavone, apigenin is one of the most biologically active flavonoids found in nature, distinguished by its low toxicity and high bioavailability.

Unlike synthetic compounds, apigenin occurs naturally in plants as a secondary metabolite, contributing to their pigmentation and defense mechanisms. Extensive research highlights its anti-aging, anti-inflammatory, antioxidant, and anti-cancer properties, making Celery Root Extract a sought-after ingredient in nutraceuticals, functional foods, and pharmaceutical formulations.

At Botanical Essence, we specialize in delivering high-purity Celery Root Extract with standardized apigenin content, ensuring consistency, efficacy, and compliance with international quality standards.

Key Active Compound: Apigenin

Apigenin is the primary bioactive constituent in Celery Root Extract, accounting for its wide-ranging health benefits. As a flavonoid, it exhibits:

  • Low cellular toxicity – Safe for long-term consumption with minimal adverse effects.
  • Potent bioactivity – Modulates cellular pathways, including NF-κB, COX-2, and iNOS, which are critical in inflammation and cancer progression.
  • High stability – Retains efficacy under various processing and storage conditions.

Scientific studies confirm that apigenin plays a pivotal role in cellular protection, immune modulation, and metabolic regulation, reinforcing its value in dietary supplements, herbal medicines, and functional beverages.

Extraction Methods: Ensuring Maximum Purity & Yield

The extraction of apigenin from celery root involves advanced, solvent-efficient techniques to preserve its bioactive integrity. Below are the industry-recognized methods employed in Celery Root Extract production:

1. Solvent Extraction (Ethanol-Based)

  • Most widely used due to ethanol’s low toxicity and high extraction efficiency.
  • Optimized parameters:
  • Ultrasonic power: 200 W
  • pH: 1.0 (acidic conditions enhance solubility)
  • Solid-liquid ratio: 1:10 (g/mL)
  • Extraction time: 90 minutes
  • Advantages: Cost-effective, scalable, and compliant with food-grade and pharmaceutical standards.

2. Acid Hydrolysis Extraction

  • Process: Celery root is subjected to sulfuric acid hydrolysis, followed by filtration, drying, and ethanol recrystallization.
  • Yield: Produces a crude apigenin extract with 64.80% purity.
  • Benefits: Simple, low-cost, and leverages apigenin’s low solubility in hot water for purification.

3. Enzymatic-Assisted Extraction

  • Mechanism: Enzymes (e.g., cellulase, pectinase) break down cell walls, releasing bound flavonoids.
  • Advantages:
  • Higher extraction rates (up to 30% more than conventional methods).
  • Milder conditions (preserves heat-sensitive compounds).
  • Eco-friendly (reduces solvent usage).

4. Ultrasonic-Microwave Assisted Extraction (UMAE)

  • Synergistic effect: Combines ultrasonic cavitation (disrupts cell structures) and microwave heating (enhances solvent penetration).
  • Optimal conditions:
  • Ethanol concentration: 20% water
  • Microwave power: 600 W
  • Solid-liquid ratio: 1:30 (g/mL)
  • Treatment time: 240 seconds
  • Result: Apigenin extraction rate of 14.156 μg/g.

5. Subcritical Water Extraction (SWE)

  • Green technology: Uses pressurized hot water (115°C, 45 bar) as a solvent.
  • Best for: Moderately polar and nonpolar flavonoids.
  • Advantages:
  • No toxic solvents – 100% eco-friendly.
  • High selectivity – Targets apigenin with minimal impurities.
  • Scalable for industrial production.

At Botanical Essence, we employ GMP-certified extraction methods to ensure maximum apigenin retention, minimal degradation, and consistent batch-to-batch quality.

Certificate of Analysis (COA) for Celery Root Extract

ParameterSpecificationTest MethodResult
AppearanceLight Yellow Fine PowderOrganolepticConforms
Loss on Drying≤5.0%USP37 <921> 2.2Conforms
Ignition Ash≤5.0%USP37 <561> 1.3Conforms
Apigenin Content98%HPLC98.2%
Heavy Metals≤10.0 mg/kgUSP37 <233>Conforms

Quality Assurance:

  • HPLC-verified apigenin purity (98% minimum).
  • Heavy metal testing (lead, arsenic, mercury, cadmium) within pharmaceutical limits.
  • Microbiological safety (total plate count, yeast, mold, E. coli, Salmonella) compliant with USP, EP, and FDA standards.

Pharmacological & Health Benefits of Celery Root Extract

1. Anti-Cancer & Anti-Tumor Properties

Cancer remains a global health challenge, characterized by uncontrolled cell proliferation, genetic mutations, and apoptosis resistance. Apigenin demonstrates potent anti-cancer activity through multiple mechanisms:

  • Inhibits cancer cell proliferation (e.g., breast, prostate, colon, lung).
  • Induces apoptosis via Bcl-2 family protein modulation.
  • Suppresses angiogenesis (prevents tumor blood vessel formation).
  • Enhances chemotherapy efficacy when used as an adjuvant.

Research Highlight: Studies published in Cancer Research and Oncogene confirm apigenin’s ability to target cancer stem cells while sparing healthy tissues.

2. Anti-Inflammatory Effects

Chronic inflammation is a root cause of degenerative diseases, including arthritis, cardiovascular disorders, and neurodegenerative conditions. Apigenin modulates inflammatory pathways by:

  • Inhibiting pro-inflammatory cytokines (TNF-α, IL-6, IL-1β).
  • Suppressing COX-2 and iNOS expression (reduces nitric oxide production).
  • Blocking NF-κB activation (a key inflammatory transcription factor).

Clinical Relevance: Effective in rheumatoid arthritis, IBD (Inflammatory Bowel Disease), and metabolic inflammation.

3. Antioxidant & Free Radical Scavenging

Oxidative stress accelerates aging, DNA damage, and chronic diseases. Apigenin acts as a potent antioxidant by:

  • Chelating metal ions (Fe²⁺, Cu²⁺) to prevent Fenton reactions.
  • Neutralizing reactive oxygen species (ROS) (superoxide, hydroxyl radicals).
  • Protecting lipids and LDL cholesterol from peroxidation.

Comparison: More effective than vitamin C and E in certain oxidative stress models.

4. Cardiovascular Support

Celery Root Extract promotes heart health through:

  • Vasodilation via NO (nitric oxide) pathway activation.
  • Inhibition of calcium influx (prevents vascular smooth muscle contraction).
  • Reduction of atherosclerotic plaque formation.
  • Improvement in endothelial function.

Mechanism: Enhances potassium channel activity while suppressing voltage-dependent calcium channels.

5. Additional Therapeutic Applications

Beyond its primary benefits, apigenin has been studied for:
✅ Blood sugar regulation (improves insulin sensitivity).
✅ Lipid-lowering effects (reduces LDL, triglycerides).
✅ Neuroprotective properties (prevents Alzheimer’s and Parkinson’s-related damage).
✅ Antiviral activity (effective against HSV-1, influenza).
✅ Bone health (stimulates osteoblast activity, prevents osteoporosis).
✅ Sedative & anxiolytic effects (modulates GABA receptors).
✅ Immune modulation (enhances autoimmune regulation).

Industrial Applications of Celery Root Extract

1. Nutraceuticals & Dietary Supplements

  • Capsules, tablets, and softgels (standardized apigenin content).
  • Functional powders (for smoothies, protein blends).
  • Anti-aging and longevity formulas.

2. Functional Foods & Beverages

  • Herbal teas and infusions (natural apigenin source).
  • Energy drinks and wellness shots (antioxidant boost).
  • Baked goods and snacks (fortified with bioactive flavonoids).

3. Pharmaceutical & Cosmeceutical Formulations

  • Anti-inflammatory drugs (adjunct therapy).
  • Topical creams and serums (skin anti-aging, UV protection).
  • Oncology research (potential chemopreventive agent).

4. Animal Health & Pet Nutrition

  • Veterinary supplements (joint health, immune support).
  • Livestock feed additives (antioxidant and anti-inflammatory benefits).

Product Specifications & Technical Details

AttributeDetails
Botanical SourceApium graveolens (Celery Root)
Part UsedRoot
Extraction SolventEthanol, Water (GMP-compliant)
Apigenin Content98% (HPLC)
AppearanceLight yellow to off-white fine powder
Mesh Size80-100 mesh (customizable)
SolubilitySoluble in ethanol, DMSO; partially soluble in water
Shelf Life2 years (when stored properly)
Storage ConditionsCool, dry place (below 25°C), sealed in airtight container
Packaging1 kg/aluminum foil bag, 25 kg/fiber drum (custom options available)
MOQ1 kg (bulk discounts for wholesale orders)

Customization Available:

  • Different apigenin concentrations (10%-99%).
  • Organic-certified extraction (upon request).
  • Private label packaging for OEM/ODM clients.

Why Choose Botanical Essence for Celery Root Extract?

✔ Premium Quality – 98% apigenin purity, verified by HPLC and third-party testing.
✔ Advanced Extraction – Ethanol, enzymatic, and subcritical water methods for maximum yield.
✔ Regulatory Compliance – Meets USP, EP, FDA, and ISO 22000 standards.
✔ Sustainable Sourcing – Non-GMO, pesticide-free celery roots from trusted agricultural partners.
✔ Global Supply Chain – Fast shipping, competitive pricing, and bulk discounts for international clients.
✔ Technical Support – Dedicated R&D team for formulation assistance and custom blends.

How to Order Celery Root Extract

For wholesale inquiries, bulk pricing, or sample requests, contact our expert team:

📧 Email: [email protected]
🌍 Website: Botanical Essence

We serve:

  • Nutraceutical manufacturers
  • Pharmaceutical companies
  • Functional food & beverage brands
  • Cosmeceutical formulators
  • Research institutions & contract labs

Available for immediate shipment – In stock, ready to dispatch worldwide!

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