Introduction to Dihydromyricetin (DHM)
Dihydromyricetin (DHM), a naturally occurring flavonoid, is a potent bioactive compound derived from select botanical sources, including Hovenia dulcis (Japanese raisin tree) and Ampelopsis grossedentata. As a key secondary metabolite, DHM belongs to the flavanonol subclass of flavonoids, characterized by its (2R,3R) optical configuration. This structurally unique compound exhibits remarkable pharmacological properties, making it a highly sought-after ingredient in the nutraceutical, pharmaceutical, and functional food industries.
Unlike synthetic alternatives, dihydromyricetin extract is sourced from traditional medicinal plants long revered in East Asian herbal medicine. Ampelopsis grossedentata, commonly known as "moyeam" or "vine tea," has been used for centuries to support respiratory health, regulate blood sugar, and promote lipid metabolism. Meanwhile, Hovenia dulcis is a staple in traditional Chinese, Japanese, and Korean medicine, valued for its detoxifying and liver-protective effects.
At Botanical Essence, we specialize in high-purity dihydromyricetin powder, ensuring consistent quality, potency, and compliance with international standards for dietary supplements, functional foods, and pharmaceutical applications.
Scientific Profile & Chemical Characteristics
Source & Extraction
Dihydromyricetin is primarily extracted from the leaves and stems of Ampelopsis grossedentata and the seeds of Hovenia dulcis through a meticulous solvent-based or supercritical CO₂ extraction process. Our dihydromyricetin bulk undergoes rigorous purification to achieve a minimum 98% active content, as verified by HPLC (High-Performance Liquid Chromatography).
Physical & Chemical Properties
| Parameter | Specification |
|---|---|
| Molecular Formula | C₁₅H₁₂O₇ |
| Molecular Weight | 320.26 g/mol |
| Appearance | Fine, off-white to light yellow powder |
| Solubility | Soluble in ethanol, DMSO, and alkaline water; slightly soluble in water |
| Stability | Stable under normal storage conditions (cool, dry, away from light) |
| Odor & Taste | Characteristic mild herbal aroma and slightly bitter taste |
Quality & Purity Standards
Our dihydromyricetin extract adheres to strict quality control measures, ensuring compliance with USP, EP, and CP (Chinese Pharmacopoeia) standards. Below is a summary of our latest Certificate of Analysis (COA):
Purity & Identity
- Active Content (HPLC): ≥98.00% (Tested: 98.07%)
- Appearance: Fine powder (Conforms)
- Color: Off-white to light yellow (Conforms)
Physical & Chemical Tests
| Test | Specification | Result | Method |
|---|---|---|---|
| Loss on Drying | ≤2.0% | 1.68% | 2 hours at 105°C |
| Ash Content | ≤1.0% | 0.44% | 5 hours at 600°C |
Heavy Metal & Contaminant Limits
| Contaminant | Specification | Result | Method |
|---|---|---|---|
| Total Heavy Metals | ≤10 ppm | Conforms | ICP-MS |
| Arsenic (As) | ≤1.0 ppm | Conforms | GB 5009.11-2014 |
| Lead (Pb) | ≤1.0 ppm | Conforms | GB 5009.12-2017 |
| Mercury (Hg) | ≤0.5 ppm | Conforms | GB 5009.17-2014 |
| Cadmium (Cd) | ≤1.0 ppm | Conforms | GB 5009.15-2014 |
Microbiological Safety
| Test | Specification | Result | Method |
|---|---|---|---|
| Total Plate Count | ≤1000 cfu/g | Conforms | CP2015 |
| Yeast & Mold | ≤100 cfu/g | Conforms | CP2015 |
| E. coli | Negative | Conforms | CP2015 |
| Salmonella | Negative | Conforms | CP2015 |
| Staphylococcus | Negative | Conforms | CP2015 |
Key Benefits & Applications of Dihydromyricetin
1. Liver Protection & Alcohol Metabolism Support
Dihydromyricetin is widely recognized for its hepatoprotective properties, particularly in alcohol detoxification. Clinical and preclinical studies suggest that DHM:
- Accelerates alcohol metabolism by enhancing ADH (alcohol dehydrogenase) and ALDH (aldehyde dehydrogenase) activity, reducing acetaldehyde toxicity.
- Mitigates hangover symptoms by minimizing oxidative stress and inflammation in the liver.
- Protects liver cells from ethanol-induced damage, supporting overall hepatic function.
2. Neuroprotective & Cognitive Benefits
- Modulates GABA receptors, promoting relaxation and reducing anxiety without sedation.
- Enhances cognitive function by protecting neurons from oxidative damage.
- May support addiction recovery by reducing alcohol cravings (studies suggest DHM’s potential in alcohol dependence management).
3. Antioxidant & Anti-Inflammatory Effects
As a potent flavonoid, dihydromyricetin exhibits:
- Strong free radical scavenging activity, neutralizing ROS (reactive oxygen species).
- Anti-inflammatory properties, inhibiting pro-inflammatory cytokines (e.g., NF-κB, TNF-α).
- Cardioprotective effects by improving endothelial function and reducing LDL oxidation.
4. Metabolic & Glycemic Regulation
- Supports blood sugar balance by enhancing insulin sensitivity.
- Aids lipid metabolism, reducing triglycerides and LDL cholesterol.
- Promotes weight management through AMP-activated protein kinase (AMPK) activation.
5. Antimicrobial & Immune Support
- Exhibits antibacterial and antiviral properties, particularly against H. pylori and influenza viruses.
- Strengthens immune response by modulating immune cell activity.
Industrial Applications of Dihydromyricetin
1. Dietary Supplements & Nutraceuticals
- Hangover relief capsules & powders (pre- and post-alcohol consumption).
- Liver detox & metabolic support formulas.
- Stress & anxiety management supplements (synergistic with L-theanine, ashwagandha).
- Sports nutrition (recovery and antioxidant support).
2. Functional Foods & Beverages
- Alcohol-free "sober-up" drinks (e.g., DHM-infused teas, energy shots).
- Functional beverages (antioxidant-enhanced juices, smoothies).
- Baked goods & snacks (fortified with DHM for metabolic benefits).
3. Pharmaceutical & Cosmeceutical Uses
- Liver-protective drug formulations (adjunct therapy for fatty liver disease).
- Topical antioxidants in skincare (anti-aging, UV protection).
4. Animal Nutrition & Feed Additives
- Livestock & poultry feed (enhances growth performance, reduces oxidative stress).
- Pet supplements (liver support for dogs and cats).
Why Choose Botanical Essence for Dihydromyricetin?
1. Premium Quality & Consistency
- High-purity DHM (≥98%) with verified HPLC testing.
- Non-GMO, solvent-free extraction (optional CO₂ extraction available).
- No additives, fillers, or artificial contaminants.
2. Stringent Quality Control
- Third-party lab testing for heavy metals, microbes, and purity.
- Compliance with FDA, EU, and Chinese Pharmacopoeia standards.
- Batch-to-batch consistency for reliable formulation.
3. Customizable Solutions
- Multiple grades available (food-grade, pharmaceutical-grade, cosmetic-grade).
- Flexible packaging (1kg–25kg foil bags, drums, or bulk shipments).
- Private labeling & OEM services for brand owners.
4. Sustainable & Ethical Sourcing
- Wildcrafted or organically cultivated raw materials.
- Traceable supply chain from farm to final product.
- Eco-friendly extraction methods with minimal environmental impact.
5. Global Supply & Logistics Support
- Fast lead times (stock available for immediate shipment).
- Competitive wholesale pricing for bulk orders.
- Export-ready documentation (COA, MSDS, Halal/Kosher certifications upon request).
Storage & Handling Recommendations
To maintain dihydromyricetin’s stability and potency:
- Store in a cool, dry place (below 25°C).
- Keep in airtight, light-resistant containers (preferably nitrogen-flushed).
- Avoid exposure to moisture, heat, or direct sunlight.
- Shelf life: 2 years under proper storage conditions.
How to Purchase Dihydromyricetin
As a leading dihydromyricetin supplier, Botanical Essence provides high-quality, bulk DHM extract for manufacturers, formulators, and distributors worldwide.
📧 Contact us today for:
✅ Competitive bulk pricing
✅ Free samples (for qualified buyers)
✅ Custom formulations & private labeling
✅ Technical support & regulatory guidance
Email: [email protected]
Whether you are developing a hangover relief supplement, a liver support formula, or a functional beverage, our dihydromyricetin powder delivers the purity, efficacy, and consistency your brand demands.
Partner with Botanical Essence—your trusted source for premium botanical extracts.
